TG Therapeutics Inc.

TGTX

Held by 6 specialist biotech funds

High ConvergenceHigh short interest · No specialist buying

6 funds opened new positions. Next phase2 readout (Ublituximab): May 2015. Short interest: 25.5% of float.

Catalysts

Phase 2Q2 2015UblituximabNon-Hodgkins Lymphoma, B-cell Lymphoma, Waldenstrom's MacroglobulinemiaNCT01647971

Primary: Number of Participants with Adverse Events as a Measure of Safety and Tolerability (Subjects will be followed for 4 weeks)Enrollment:39/39Sites: 8NA, TREATMENT

Phase 2Q4 2015UblituximabChronic Lymphocytic Leukemia, Mantle Cell LymphomaNCT02013128

Primary: To evaluate the safety of ublituximab in combination with ibrutinib in patients with select B-cell malignancies (28 days (1 cycle of therapy))Enrollment:66/66Sites: 18NA, TREATMENT

Phase 2PositiveQ3 2017UblituximabMultiple SclerosisNCT02738775

Primary: Responder Rate of B-Cell Depletion at Week 4 (Week 4)Enrollment:49/49Sites: 12RANDOMIZED, DOUBLE, TREATMENT

Phase 3Q2 2020UblituximabChronic Lymphocytic LeukemiaNCT02301156

Primary: Overall Response Rate (ORR) (Up to 62 months)Enrollment:126/126Sites: 88RANDOMIZED, TREATMENT

Phase 3PositiveQ3 2020UblituximabRelapsing Multiple Sclerosis (RMS)NCT03277261

Primary: Annualized Relapse Rate (ARR) (Up to 96 weeks)Enrollment:549/549Sites: 14RANDOMIZED, QUADRUPLE, TREATMENT

Phase 3PositiveQ3 2020UblituximabRelapsing Multiple Sclerosis (RMS)NCT03277248

Primary: Annualized Relapse Rate (ARR) (Up to 96 weeks)Enrollment:545/545Sites: 13RANDOMIZED, QUADRUPLE, TREATMENT

Phase 2NegativeQ2 2021UmbralisibChronic Lymphocytic LeukemiaNCT02742090

Phase 2PositiveQ1 2022UmbralisibMarginal Zone Lymphoma, Waldenstrom Macroglobulinemia, Non Follicular Indolent Non-Hodgkin LymphomaNCT03364231

Phase 2NegativeQ2 2022UblituximabFollicular Lymphoma, Small Lymphocytic LymphomaNCT03828448

Phase 2NegativeQ2 2022UblituximabChronic Lymphocytic LeukemiaNCT04016805

Phase 2NegativeQ2 2022TGR-1202Chronic Lymphocytic Leukemia, Non Hodgkin LymphomaNCT03207256

Phase 2NegativeQ2 2022UblituximabChronic Lymphocytic LeukemiaNCT02656303

Phase 2NegativeQ2 2022VenetoclaxChronic Lymphocytic Leukemia, Non-Hodgkin LymphomaNCT03379051

Phase 2Q4 2022UblituximabRelapsing Remitting Multiple SclerosisNCT03381170

Phase 3NegativeQ4 2022UblituximabChronic Lymphocytic Leukemia, Small Lymphocytic LymphomaNCT03801525

Phase 3Q4 2026UblituximabRelapsing Multiple SclerosisNCT07211633

Primary: Area Under the Curve From Week 0 to Week 24 (AUC0-W24) of Ublituximab (Up to Week 24)Enrollment:Target 360Sites: 42RANDOMIZED, TREATMENT

Phase 2Q3 2027UblituximabMultiple SclerosisNCT07503873

Phase 3Q4 2027UblituximabRelapsing Multiple SclerosisNCT05877963

Phase 3Q1 2030UblituximabRelapsing Multiple SclerosisNCT07220252

Primary: Part A: Area Under the Curve From Week 0 to 24 (AUC0-W24) of Ublituximab (Predose and multiple timepoints up to Week 24)Enrollment:Target 240RANDOMIZED, QUADRUPLE, TREATMENT

Phase 3Q2 2032UblituximabRelapsing Multiple Sclerosis (RMS)NCT04130997

TG Therapeutics Inc.

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